is an orally active small molecule drug that crosses
the blood brain barrier and promotes nerve cell growth.
ABS-205 exhibits nerve growth factor (NGF)-like activity.
NGF and other neurotrophic protein molecules are present
in the brain to protect nerve cells from injury. Aging
and neurodegeneration are associated with loss of
nerve cells and associated memory deficits. Neurodegeneration
can be subdivided into acute and chronic disease conditions.
Acute neurodegeneration occurs after stroke and trauma
and results in rapid loss of nerve cells. Chronic
neurodegeneration involves the loss of brain cells
over many years and is associated with Alzheimer's
disease and Parkinson's disease. Neurotrophic factors
have the potential to alleviate the effects of these
conditions, but are restricted by poor brain penetration.
ABS-205, is an organic molecule and can therefore
readily cross the blood brain barrier into brain tissue.
ABS-205 also protects against memory loss in animal
models and preserves the loss of nerve cell connections,
which occurs with aging. ABS-205 is well tolerated
by experimental animals and is not associated with
overt organ toxicity.
activity and memory enhancing effects of ABS-205 suggest
that this compound is useful as a treatment for memory
loss and neurodegeneration associated with aging,
stroke, trauma, Alzheimer's disease and Parkinson's
disease. ABS-205 also reduces cell division.
ABS-205 stimulates the formation of new brain connections
in nerve cell lines.
ABS-205 crosses into the brain accumulating
where it is needed in brain regions involved in learning
and memory processing.