ABS is developing a number of promising neurological
compounds for the treatment of epilepsy, migraine,
mania and neurodegenerative disorders such as Alzheimer's
disease, neuropathy and stroke. These compounds are
designed to meet significant unmet clinical needs
in treatments for these disorders.
ABS' lead compound, ABS-103R
is designed to be a next generation replacement for
the widely used drug valroate. Valproate is used to
treat epilepsy, migraine and mania but is associated
with significant toxicity. ABS-103R is a potent single
isomer analogue of a valproate specifically engineered
to have the same efficacy yet without the dangerous
side effects.
ABS-205 is an orally active
small molecule drug that crosses the blood brain barrier
and promotes nerve cell growth. The neurothrophic
activity and memory enhancing effects of ABS-205 suggest
that this compound is useful as a treatment for memory
loss and neurodegeneration associated with aging,
stroke, trauma, Alzheimer's
disease and Parkinson's
disease and also reduces cell division.